Specific Parameters of Toxic Reactions in Rats to the Combination of Delamanid and Drugs for Treatment of Drug Resistant Tuberculosis (A Pilot Study)

The objective : to evaluate the toxicity of combinations delamanid and drugs for treatment drug resistant tuberculosis with different safety profiles in an experiment. Results . During 14 days study, animals both experimental groups satisfactorily tolerated administration combinations, no died, negative impact on body weight changes was observed (physiological gain). In rats from Group OG-1, change skin color (orange tint) noted. This tissue is adverse reaction, but according literature [4], it reversible. prolongation QT interval ECG treated combination cardiotoxic potential (Dlm, Bdq, Cfz, Pto) insignificant, Dlm, Lzd, Cs, Pto did not differ baseline level. neurotoxicity manifested through a decrease motor exploratory activity. A activity against background preservation their There were significant laboratory morphometric parameters compared control group.